LDL receptor affects the skeletal muscle and bone microstructure of female mouse through the Wnt/β-catenin signaling pathway.

Yue Hu, Huiling Liu, Chaoyue Zhao, Peizhao Shi, Meiqing Lu, Yanli Chen, Xiaoyan Fang, Lingling Huang, Zhikun Bai, Jinhua Wang, Hai Li

School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China.School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China. · pubmed

Paper

Abstract

Osteosarcopenia, a composite disorder of age-related sarcopenia and osteoporosis, currently lacks targeted therapeutic interventions. We hypothesized that skeletal muscle-specific LDLR knockdown could reverse musculoskeletal functional decline via the Wnt/β-catenin signaling pathway.

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Research summary

The paper claims that skeletal muscle-specific LDLR knockdown can reverse musculoskeletal functional decline via the Wnt/β-catenin signaling pathway. This research addresses the underlying mechanisms of osteosarcopenia, which is directly related to aging and its associated decline in musculoskeletal health.

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