Impact of telomere length alteration in chronic kidney disease patients of Pakistan: a case-control study and meta-analysis of 24,089 patients.

Minahil Tahir, Afrose Liaquat, Fareeha Khalil, Zuha Tariq, Arham Javed, Aleezay Irfan, Muhammad Jawad Khan

Department of Biosciences, COMSATS University, Islamabad, Pakistan.Department of Biosciences, COMSATS University, Islamabad, Pakistan. · pubmed

Paper

Abstract

Chronic kidney disease (CKD) is becoming a global health concern due to its rising prevalence owing to the complex interplay of environmental, genetic, and epigenetic factors. Leukocyte telomere length (LTL) is a potential indicator of biological age in age-related diseases. Our objective is to investigate the association between LTL and CKD in Pakistani population to systematically synthesize existing evidence by investigating previously reported studies.

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Research summary

The paper investigates the association between leukocyte telomere length and chronic kidney disease in a specific population. This research is relevant as it explores a potential biomarker of biological aging in the context of a disease that is influenced by aging processes.

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