Benefits of Oral Nitrite Supplementation on Mitochondrial Respiration and Physical Function In Older Adults.

Daniel E Forman, Subashan Perera, Sruti Shiva, Nancy W Glynn, Tara Teahan Stakich, Sofhia V Ramos, Giovanna Distefano, Cody Wolf, Angelina Kendi, Adam Sterczala, Ian J Sipula, Fiona M Bello, Michael J Jurczak, Frank C Sciurba, Mark T Gladwin, Anne B Newman, Paul M Coen

Department of Medicine, University of Pittsburgh (Divisions of Geriatrics and Cardiology), and Geriatrics, Research, Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA.Department of Medicine, University of Pittsburgh (Divisions of Geriatrics and Cardiology), and Geriatrics, Research, Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA. · pubmed

Paper

Abstract

Age-associated decline in mitochondrial oxidative capacity is associated with increased risk of disease, frailty, and disability. Oral nitrite and nitrate supplementation have been demonstrated to improve mitochondrial energetics and physical function in younger adults, but effects in older adults (age ≥70 years) remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Oral nitrite supplementation improves mitochondrial respiration and physical function in older adults. This research addresses the decline in mitochondrial function associated with aging, which is a root cause of age-related diseases and frailty.

Author of this paper? Send a correction.