Genetic insights into biological aging and myasthenia gravis: a Mendelian randomization study of telomere length, epigenetic clocks, and mitochondrial DNA copy number.

Wei Xiang, Yining Luan, Kangzhi Chen, Ting He, Qian Zhou, Huan Yang

Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410018, China.Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410018, China. · pubmed

Paper

Abstract

Emerging epidemiological evidence shows myasthenia gravis (MG) is associated with age-related biological processes, but its mechanism of causality remains unexplained. This bidirectional Mendelian randomization (MR) study aimed to clarify the causal relationships between quantifiable biomarkers of aging and MG.

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Research summary

This study investigates the causal relationships between biomarkers of aging and myasthenia gravis. The paper is relevant as it explores genetic insights into biological aging, which could contribute to understanding age-related diseases and their underlying mechanisms.

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