Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons.

Eric R McGregor, Katie J Osterbauer, Grace E Gustafson, Josef P Clark, Timothy W Rhoads, Rozalyn M Anderson

Department of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States.Department of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States. · pubmed

Paper

Abstract

Adiponectin is an adipose tissue-derived peptide hormone that exerts beneficial metabolic effects in many tissues throughout the body. It is most well-known for its ability to enhance insulin sensitivity and dampen chronic inflammation. The impact of age on adiponectin is controversial; levels of adiponectin in circulation in older individuals have been linked to both positive and negative effects. This review integrates genetic, mechanistic, and therapeutic perspectives on adiponectin in aging. Specific considerations that might explain the "adiponectin paradox" are described and discussed. We present potential future applications of adiponectin-based strategies to prevent age-related metabolic dysfunctions and lower the risk for age-related chronic conditions.

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Research summary

The paper discusses the role of adiponectin in aging and its potential therapeutic applications to address age-related metabolic dysfunctions. This research is relevant as it explores mechanisms that could contribute to understanding and potentially mitigating the root causes of aging-related issues.

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