8-Oxoguanine modifications in seed regions of miRNAs regulating P16 promote aging by reshaping gene regulatory networks.

Jia-Qi Guo, Qing-Yu Wang, Ying-Min Zhang, Jin Li, Lan Yang, Xiao Zhang, Ming-Ming Han, Huan Xi, Ruo-Mei Qi, Jian-Ping Cai

The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Medical School, University of Chinese Academy of Sciences, Beijing, China; Department of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Medical School, University of Chinese Academy of Sciences, Beijing, China; Department of Geriatrics, National Clinical Research Center for Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. · pubmed

Paper

Abstract

The mechanisms underlying upregulation of P16, a key marker of cellular senescence, during the senescence process remain unclear. We observed that miR-134-5p and miR-3118 effectively inhibited P16 expression and delayed cellular senescence in human dermal fibroblast cells. The reactive oxygen species-induced 8-oxo-guanine (o

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Research summary

The paper claims that miR-134-5p and miR-3118 inhibit P16 expression and delay cellular senescence. The research addresses mechanisms of cellular senescence, which is directly related to aging processes.

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