Stress endurance mediates the healthspan-promoting effect of two newly described iridoid glycosides from Verbascum nigrum ssp. abietinum in Caenorhabditis elegans.

Slaveya Krustanova, Monika N Todorova, Vanya Gerasimova, Martina S Savova, Stoyan Stoyanov, Milena P Popova, Milen I Georgiev, Kalina Alipieva

Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; Centre of Competence "Sustainable Utilization of Bio-resources and Waste of Medicinal and Aromatic Plants for Innovative Bioactive Products" (BIORESOURCES BG), Sofia, Bulgaria. · pubmed

Paper

Abstract

Natural products are emerging as promising options for promoting health and managing age-related diseases. Iridoid glycosides, a diverse class of monoterpenoids, exert multiple beneficial effects and are of significant interest in pharmaceutical research. They are abundant in Scrophulariaceae, particularly in the genus Verbascum L. (mulleins). However, the infraspecific taxon V. nigrum ssp. abietinum (Borbas) I.K. Ferguson, native to the Balkan Peninsula, has not been previously investigated regarding chemical composition or healthspan-modulating potential.

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Research summary

The paper claims that stress endurance mediates the healthspan-promoting effect of iridoid glycosides from Verbascum nigrum ssp. abietinum in C. elegans. This research is relevant as it explores natural compounds that may influence healthspan and longevity through mechanisms related to stress resilience, which aligns with the broader goals of longevity research.

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