Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence.

Jinmeng Chu, Qingzhi Zhao, Yizhen Wang, Chengyu Cai, Xueli Cui, Na Zhang, Tiantian Xu, Haoqing Dou, Fei Wang, Feiran Yu, Yong Cai, Jingji Jin

School of Life Sciences, Jilin University, Changchun City, Jilin 130012, China. Electronic address: [email protected] of Life Sciences, Jilin University, Changchun City, Jilin 130012, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Mitochondria are central regulators of cellular energy metabolism and its dysfunction drives cellular senescence. CISD2, a mitochondrial outer membrane protein and longevity gene, declines with age, highlighting its role in cellular senescence; however, how its post-translational modifications (PTMs) regulate cellular senescence remains poorly understood.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Ginsenoside Rg5 targets the KAT8-CISD2 axis to maintain mitochondrial homeostasis and antagonize senescence. The paper addresses the role of CISD2, a longevity gene, in cellular senescence and mitochondrial function, which are central to understanding the mechanisms of aging.

Author of this paper? Send a correction.