Mechanisms of Phthalate-Induced Accelerated Ovarian Aging in Experimental Models.
Abstract
Accelerated ovarian aging is associated with early infertility as well as other adverse health outcomes. Little is known about the factors that accelerate ovarian aging, but several studies indicate that exposure to phthalates accelerates ovarian aging. This is a significant human health concern because humans are ubiquitously and unavoidably exposed to phthalates. Thus, it is imperative to study the mechanisms of phthalate-induced accelerated ovarian aging so that strategies can be developed to prevent phthalate-induced ovarian aging. This review focuses on the mechanisms by which phthalates cause ovarian aging in non-human experimental models and highlights gaps in the literature.
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Research summary
Phthalates accelerate ovarian aging through specific mechanisms in experimental models. The study addresses a potential root cause of accelerated aging in the ovarian context, which is relevant to understanding and potentially mitigating age-related reproductive health issues.
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