Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice.

Veronica Bergo, Pavlos Bousounis, Giang To Vu, Mélodie Douté, Aikaterini Polyzou, Maria-Eleni Lalioti, Bogdan B Grigorash, Lyudmila Tsurkan, Nicholas Morchel, Ward Deboutte, Frédéric Brau, Thomas Manke, Hind Medyouf, Dmitry V Bulavin, Nina Cabezas-Wallscheid, Marta Derecka, Eirini Trompouki

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. [email protected] Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. [email protected]. · pubmed

Paper

Abstract

"Inflammaging", the chronic increase in inflammatory signaling with age, remains poorly understood in hematopoietic aging. Here, we identify the innate immune RNA sensor melanoma differentiation-associated protein 5 (MDA5) as an important factor of hematopoietic stem cell (HSC) aging. Aged Mda5

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Research summary

The paper claims that the lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice. This research addresses the mechanisms underlying hematopoietic aging, which is a fundamental aspect of the aging process and could contribute to understanding and potentially mitigating age-related decline.

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