Telomere length in patients with Marfan Syndrome.

Tijs K Tournoy, Simon D'hulst, Anthony Demolder, Robbe Derudder, Dries S Martens, Laura Muiño Mosquera, Paul Coucke, Julie De Backer

Department of Cardiology, Ghent University Hospital, Ghent, Belgium. Electronic address: [email protected]. · pubmed

Paper

Abstract

Marfan syndrome (MFS) is a multisystemic heritable thoracic aortic disease entity characterized by progressive aortic dilatation and life-threatening cardiovascular complications. Chronic inflammation and oxidative stress are increasingly recognized in its pathophysiology, and are important drivers of telomere shortening, a hallmark of biological aging. We hypothesized that adults with MFS have shorter telomere length (TL) compared to healthy controls.

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Research summary

Adults with Marfan Syndrome have shorter telomere length compared to healthy controls. The study explores the relationship between telomere length and a genetic condition, which may provide insights into biological aging mechanisms.

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