Discovery of Glycation-Derived Cross-links at Arginine.
Abstract
Glycation cross-links account for more than 40% of all known advanced glycation end products (AGEs) and are correlated with many age-related diseases. Despite much interest, cross-linking AGEs (xl-AGEs) remain poorly understood, as they have been challenging to discover, prepare, and quantify. Here, we describe a peptide platform that is ideally suited for the study of xl-AGEs, which not only facilitates direct comparisons between the prevalence of known xl-AGEs and other AGEs but also enables the discovery of previously unknown xl-AGEs. In this study, we use this platform to discover the first known Arg-Arg xl-AGEs, a pair of
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Research summary
The paper claims to discover new glycation-derived cross-links at arginine that could enhance understanding of advanced glycation end products (AGEs) in age-related diseases. The research is relevant as it addresses the mechanisms of glycation, which are implicated in the aging process and age-related diseases, potentially contributing to the understanding of aging's root causes.
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