LncRNA Gm44981 modulates EZH2-H3K27me3-p21 axis to suppress mesangial cell senescence and kidney aging.

Jie Li, Limin Wei, Fanfan Gao, Lu Zeng, Hongli Jiang, Lei Chen

Dialysis Department of Nephrology Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.Dialysis Department of Nephrology Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. · pubmed

Paper

Abstract

Aging imposes significant influence in alteration of organ structure, function, and susceptibility to disease. Long non-coding RNAs (lncRNAs) are frequently dysregulated in the aging kidney, however, the key lncRNAs and associated mechanism involved in regulating kidney aging remains poorly investigated. Herein, we performed unbiased whole transcriptome sequencing on the kidney tissue samples from young and aging mice. The results of differentially expressed lncRNAs among two groups revealed that

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Research summary

The paper claims that lncRNA Gm44981 modulates the EZH2-H3K27me3-p21 axis to suppress mesangial cell senescence and kidney aging. This research addresses mechanisms involved in kidney aging, which is a fundamental aspect of the aging process and could contribute to understanding and potentially mitigating age-related decline in kidney function.

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