Iron dysregulation and mitochondrial dysfunction in aging: A longitudinal study on mobility decline in low- and high-functioning older adults.

Nevena Stanojevic, Stephanie Wohlgemuth, Rola S Zeidan, XiangYang Lou, Javier A Tamargo, Bella Bravo, Jennifer Newman, Anna Picca, Emanuele Marzetti, Kevin Wu, Christian McLaren, Robert Mankowski, Bhanuprasad Sandesara, Aditya Shirali, Todd Manini, Christiaan Leeuwenburgh, Stephen Anton

University of Florida, Department of Physiology and Aging, Gainesville, FL, USA. Electronic address: [email protected] of Florida, Department of Physiology and Aging, Gainesville, FL, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

Mobility loss in older adults reduces quality of life and increases risks of falls, hospitalizations, and mortality. Low-functioning (LF) older adults experience faster mobility decline than their high-functioning (HF) peers, but the underlying biological mechanisms remain unclear. Although iron accumulation in aging muscle mitochondria has recently been linked to lower physical function, its longitudinal impact on physical function remains understudied.

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Research summary

The paper investigates the relationship between iron accumulation in muscle mitochondria and mobility decline in older adults. This research is relevant as it explores potential biological mechanisms underlying aging-related mobility decline, which could contribute to understanding and addressing root causes of aging.

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