Targeted Hepatic Methylation-Controlled J Protein Inhibition Mitigates Postsurgical Liver Injury and Neuroinflammation in Aged Mice.

Kenneth Meza Monge, Akshay Pratap, Kevin M Najarro, Travis M Walrath, Mercedes Rincon, Rachel H McMahan, Elizabeth J Kovacs, Juan-Pablo Idrovo

Division of GI, Trauma and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.Division of GI, Trauma and Endocrine Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado. · pubmed

Paper

Abstract

Advanced age significantly increases postoperative complication risk, including neurological dysfunction. While the liver plays a critical role in surgical recovery, age-related changes in hepatic function remain inadequately studied in perioperative risk assessment. Methylation-Controlled J protein (MCJ), an endogenous negative regulator of mitochondrial function, represents a promising therapeutic target due to its role in exacerbating oxidative stress and compromising metabolic resilience in aging.

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Research summary

Targeted inhibition of Methylation-Controlled J protein can reduce postoperative liver injury and neuroinflammation in aged mice. The paper addresses a potential therapeutic target that may mitigate age-related complications, contributing to understanding the mechanisms underlying aging and recovery processes.

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