Aerobic exercise facilitates p300 nuclear translocation via ADRB2-AMPKα signaling, leading to enhanced histone acetylation and mitigation of cognitive decline in APP/PS1 mice.

Gao-Shang Chai, Tian-Long Gao, Shu-Guang Bi, Yu-Ming Mao, Liu Yang, Fang-Zhou Wang, Jia Chen, Jia-Jun Wu, Juan Gong, Shan Geng, Jia-Qi Yuan, Ke-Yu Zhang, Hai-Yan Yi, Zi-Chong Lan, Yun-Juan Nie, Haitao Yu

Department of Fundamental Medicine, Wuxi School of Medicine , Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China. [email protected] of Fundamental Medicine, Wuxi School of Medicine , Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China. [email protected]. · pubmed

Paper

Abstract

Physical activity (PA) is strongly associated with enhanced cognitive resilience and a lower risk of Alzheimer's disease (AD) in the aging population. However, the molecular mechanisms linking exercise-induced neuroprotection to epigenetic remodeling remain poorly defined.

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Research summary

Aerobic exercise enhances histone acetylation through p300 nuclear translocation, potentially mitigating cognitive decline in Alzheimer's disease models. This research addresses the molecular mechanisms of exercise-induced neuroprotection, which is pertinent to understanding and potentially combating age-related cognitive decline.

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