Photoprotection from UV light-induced telomere shortening and DNA damage by a broad-spectrum sunscreen.

D Hernández-Silva, M Matabuena, A Guío-Carrión, J Aguilera, A Martín, D Megias, D Mínguez, A L Demessant-Flavigny, I Castillejo, F Bernerd, L Prieto, M A Blasco

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. · pubmed

Paper

Abstract

Ultraviolet (UV) radiation contributes to photoaging and skin cancer by causing DNA damage and generating reactive oxygen species (ROS). It also induces telomere shortening, a key factor in cellular aging. However, no studies have investigated whether sunscreen can prevent short-term telomere shortening caused by UV exposure to human skin.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that broad-spectrum sunscreen can prevent UV-induced telomere shortening and DNA damage in human skin. This research is relevant as it addresses a mechanism (telomere shortening) that is associated with cellular aging and longevity.

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