Afzelin resists UVA damage through autophagy and synergizes with ganoderic acid A to skin photoaging.

Jia-Hua Zou, Mei-Ling Tai, Bao-Ying Li, Jian-Jun Liu, Zhi-Meng Zhang, Han Wang, Dong-Li Zhang, Zhuang Zhou, Shan-Shan Feng, Man-Mei Li, Zhong Liu

State Key Laboratory of Bioactive Molecules and Druggability Assessment & College of Pharmacy, Jinan University, Guangzhou, China; Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. · pubmed

Paper

Abstract

Chronic UVA exposure accelerates photoaging by inducing oxidative stress and mitochondrial dysfunction. Autophagy maintains dermal homeostasis, but its decline promotes aging. Afzelin, a flavonoid with antioxidant activity, has not been fully studied for its autophagy-related photoprotective effects.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Afzelin enhances autophagy and protects against UVA-induced skin damage, potentially mitigating photoaging. The study addresses mechanisms related to aging and cellular maintenance, which are central to longevity research.

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