Resilient Biophysical Phenotype of Memory CD4
Abstract
Age-related alterations in the immune system-collectively known as immunosenescence-include both quantitative and qualitative changes across various immune cell populations, including B cells, natural killer cells and T lymphocytes, affecting their structure, phenotype and function. While these changes have been characterised biochemically and physiologically, their biophysical manifestations remain less understood, particularly in individuals that achieve exceptional longevity. Here, we investigate the mechanical and structural properties of memory CD4
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Research summary
The paper investigates the mechanical and structural properties of memory CD4 T cells in the context of immunosenescence and exceptional longevity. This research is relevant as it explores the biophysical aspects of immune aging, which could contribute to understanding the mechanisms underlying longevity and age-related immune function.
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