Lithium and the Brain-Bone Axis: A Bridge between Osteoporosis and Alzheimer's Disease.

Ji-Won Lee, Tomoka Hasegawa, Aoi Ikedo, Kaito Mizuno, Norio Amizuka, Sek Won Kong

Department of Oral Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060-8586, Japan. · pubmed

Paper

Abstract

We evaluate the converging evidence positioning lithium as a systemic modulator of bone and brain health through shared molecular pathways. This review examines the molecular basis, preclinical data, and clinical observations suggesting that lithium-long established as first-line therapy for bipolar disorder-may simultaneously protect against osteoporosis and neurodegeneration as two clinical conditions increasingly recognized to share biological substrates.

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Research summary

Lithium may serve as a systemic modulator that links bone health and neuroprotection. The paper explores the intersection of osteoporosis and neurodegeneration, which are both age-related conditions, suggesting a potential pathway for addressing underlying mechanisms of aging.

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