Telomeres and Telomerase.

Julia Promisel Cooper, Eros Lazzerini Denchi, Joachim Lingner, Hilda A Pickett

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA [email protected] [email protected] [email protected] [email protected] of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA [email protected] [email protected] [email protected] [email protected]. · pubmed

Paper

Abstract

Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution. This volume presents an integrated collection of perspectives spanning telomere architecture, replication dynamics, telomere-driven genome instability, and telomere maintenance by telomerase and Alternative Lengthening of Telomeres (ALT), while also charting new therapeutic directions grounded in telomere biology. Drawing on molecular, structural, organismal, and clinical research, this collection showcases a field in rapid motion, reshaping our view of regeneration, aging, and disease.

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Research summary

The paper discusses the role of telomeres and telomerase in aging and genome stability, suggesting that understanding these mechanisms can inform approaches to lifespan extension and age-related decline. The focus on telomere biology and its implications for regeneration and aging makes it relevant to longevity research.

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