Replicated evidence for an accelerated rate of whole-body aging in schizophrenia.

Ethan T Whitman, Roberta Passiatore, Annchen R Knodt, Giulio Pergola, Linda A Antonucci, Alessandro Bertolino, Giuseppe Blasi, Enrico D'Ambrosio, Maxwell L Elliott, Gianluca C Kikidis, Annalisa Lella, Antonella Lupo, Alessandra Raio, Antonio Rampino, Nicola Sambuco, Pierluigi Selvaggi, Daniel R Weinberger, Terrie E Moffitt, Avshalom Caspi, Ahmad R Hariri

Department of Psychology and Neuroscience, https://ror.org/00py81415Duke University, Durham, NC, USA.Department of Psychology and Neuroscience, https://ror.org/00py81415Duke University, Durham, NC, USA. · pubmed

Paper

Abstract

People with schizophrenia develop more chronic diseases at a younger age and die younger than people in the general population. It has been hypothesized that this excess morbidity and mortality could be partially due to accelerated aging in schizophrenia. If true, this would motivate the development of 'gero-protective' interventions to reduce chronic disease burden in schizophrenia. However, it has been difficult to test this hypothesis, in part, due to the limited ability to measure aging in samples of people with schizophrenia.

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Research summary

The paper claims that schizophrenia is associated with an accelerated rate of whole-body aging. This is relevant as it explores the potential underlying mechanisms of aging in a specific population, which could inform interventions aimed at mitigating age-related diseases.

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