Buyang Huanwu Decoction attenuates vascular aging by suppressing the pathway of neutrophil extracellular trap formation via modulation of the HMGB1/TLR4/p38 signaling pathway.

Nan Xiao, Jinsong Gao, Yutong Yang, Chenghui Li, Xuejuan Shen, Xiangyu Chen, Xiaodie Chen, Yanbin Pan, Huiqun Huang, Simin Yang, Shuting Zeng, Xiaodong Duan, Yongan Deng, Chengkai Chen, Yixuan Huang, Danping Huang, Zunpeng Shu, Li Zhang

Cardiology Department, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, China; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, Guangdong, 519087, China.Cardiology Department, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510080, China; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, Guangdong, 519087, China. · pubmed

Paper

Abstract

Vascular aging is a significant driver of age-related cardiovascular diseases, in which the immune-inflammatory response driven by excessive formation of neutrophil extracellular traps (NETs) is a core process accelerating this progression. Buyang Huanwu Decoction (BHD) is a classic traditional Chinese medicine (TCM) formula widely used for treating cardio-cerebrovascular diseases, but whether it acts through modulating NET-driven vascular aging is unknown.

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Research summary

Buyang Huanwu Decoction reduces vascular aging by inhibiting neutrophil extracellular trap formation through the HMGB1/TLR4/p38 signaling pathway. The paper addresses a mechanism related to vascular aging, which is a significant aspect of the aging process and age-related diseases.

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