A tRNA-derived RNA fragment protects skin from photoaging by preserving collagen and mRNA stability.

Xiaoxi Dai, Yu Hu, Dan Huang, Zhuohong Xu, Lihao Liu, Pianpian Hong, Kun Chen, Jiaan Zhang

Department of Physiotherapy, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.Department of Physiotherapy, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. · pubmed

Paper

Abstract

Photoaging, a major form of extrinsic skin aging, primarily results from chronic ultraviolet (UV) irradiation. Although accumulating evidence implicates transfer RNA-derived small RNAs (tsRNAs) in aging, inflammation and oxidative stress, their precise roles in photoaging remain insufficiently defined.

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Research summary

The paper claims that a tRNA-derived RNA fragment can protect skin from photoaging by preserving collagen and mRNA stability. This research addresses a mechanism related to skin aging, which is a component of the broader field of longevity and aging.

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