Antioxidant and anti-aging activities of Salvia miltiorrhiza Bunge callus extracts in H

Shinn-Zong Lin, Tzu-Kai Lin, Wei-Wen Kuo, Shih-Wen Kao, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Yueh-Min Lin, Tsung-Jung Ho, Shang-Chuan Ng, Chih-Yang Huang

Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. · pubmed

Paper

Abstract

Dermal fibroblasts are pivotal in maintaining skin integrity through extracellular matrix (ECM) production, a process compromised during aging due to oxidative stress from excessive reactive oxygen species (ROS). Salvia miltiorrhiza Bunge (Danshen, DS), a medicinal plant rich in bioactive compound-rich dried roots, has demonstrated broad therapeutic potential. This study investigates the anti-aging properties of Danshen callus (DSC)-an undifferentiated cell mass derived from leaf tissue culture, as a sustainable and controlled source of bioactive compounds. Using hydrogen peroxide (H

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Research summary

The paper claims that Salvia miltiorrhiza Bunge callus extracts exhibit antioxidant and anti-aging activities in dermal fibroblasts. The study addresses oxidative stress and its role in aging, focusing on a potential solution to improve skin integrity, which is relevant to longevity research.

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