Procyanidin C1 from hawthorn modulates metabolic-inflammatory axis to combat vascular senescence in atherosclerosis.

Min Li, Jia-Yao Si, Peng-Fei Xie, Zhen-Jie Feng, Sheng-Jie Li, Feng Zhou, Jian-Mei Li

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China; School of Food Science, NanJing Xiaozhuang University, Nanjing 210023, China.School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China; School of Food Science, NanJing Xiaozhuang University, Nanjing 210023, China. · pubmed

Paper

Abstract

The global aging crisis has increased the risk of atherosclerosis (AS), positioning vascular senescence as a critical therapeutic target. Procyanidin C1 (PCC1), a bioactive polyphenol from hawthorn, demonstrates dual senolytic and longevity-enhancing effects. This study explored the regulatory role and mechanisms of PCC1 in AS using an ApoE

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Research summary

Procyanidin C1 from hawthorn modulates the metabolic-inflammatory axis to combat vascular senescence in atherosclerosis. The study addresses the underlying mechanisms of vascular senescence, which is a key aspect of aging and longevity, rather than merely treating symptoms of age-related diseases.

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