Antigen-specific T

Ines Sturmlechner, Abhinav Jain, Jingjing Jiang, Hirohisa Okuyama, Yunmei Mu, Maryam Own, Cornelia M Weyand, Jörg J Goronzy

Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA. · pubmed

Paper

Abstract

Older adults are susceptible to infections in part due to waning of immune memory. To uncover mechanisms of a long-lasting immune memory, we contrasted varicella zoster virus antigen-specific memory T cell responses in adults vaccinated at young (<20 years) or older age (>50 years) with a live-attenuated vaccine conferring durable protection only when given at young age or with an adjuvanted component vaccine eliciting long-lasting immunity in older adults. Unlike VZV-specific CD4

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Research summary

The paper investigates the mechanisms of long-lasting immune memory in older adults through the comparison of T cell responses to different vaccines. This research is relevant as it addresses the decline in immune function associated with aging, which is a critical aspect of longevity and age-related health.

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