Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis.

Melissa A Chapnick, Elaine A Yu, Alicia K Smith, Karen N Conneely, Manuel Ramírez-Zea, Zhaohui S Qin, Lisa R Staimez, Viola Vaccarino, Aryeh D Stein

Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA.Doctoral Program in Nutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA. · pubmed

Paper

Abstract

Epigenetic clocks, biomarkers of aging, show older biological ages among individuals with cardiometabolic disease. Epigenetic age acceleration, often calculated as the residuals from regressing epigenetic age on chronological age, reflects when an individual's biological age is older or younger than expected. Most clocks were developed and validated in Western populations. This study examined associations of epigenetic age acceleration with obesity, hypertension, diabetes, and metabolic syndrome among Guatemalan adults.

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Research summary

The paper claims that epigenetic age acceleration is associated with cardiometabolic diseases in Guatemalan adults. This study is relevant as it explores biological aging markers in relation to age-related diseases, contributing to the understanding of aging mechanisms in a non-Western population.

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