INTERPLAY BETWEEN PERIPHERAL AND CNS MYELOID CELLS DURING AGING: IMPACT FOR LATE-LIFE DEPRESSION AND ALZHEIMER'S DISEASE.
Abstract
Aging is associated with enumerative and functional changes of peripheral innate immune cells, notably myeloid cells (ex., monocytes/macrophages and neutrophils). Peripheral myeloid cells routinely infiltrate the brain, particularly at the brain borders, influencing cognition, mood, and stress responses.
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Research summary
The paper claims that the interplay between peripheral and CNS myeloid cells during aging influences late-life depression and Alzheimer's disease. This research is relevant as it explores the role of immune cell changes in aging, which could contribute to understanding the underlying mechanisms of age-related diseases.
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