Sex-specific nonlinear DNA methylation aging trajectories reveal biomarkers of cancer risk and inflammation.

Robin Grolaux, Macsue Jacques, Bernadette Jones-Freeman, Steve Horvath, Andrew Teschendorff, Nir Eynon

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia. · pubmed

Paper

Abstract

Aging is a multi-modal process, leaving distinct molecular signatures across the epigenome. DNA methylation is among the most robust biomarkers of biological aging, yet most studies assume linear age relationships and analyze mixed-sex cohorts, overlooking known sex differences. Such approaches risk obscuring critical nonlinear transitions and sex-specific trajectories.

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Research summary

The paper claims that sex-specific nonlinear DNA methylation aging trajectories can serve as biomarkers for cancer risk and inflammation. This research is relevant as it explores the molecular mechanisms of aging and their implications for age-related diseases, potentially contributing to a deeper understanding of biological aging processes.

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