Ginsenoside Rb1 Targets the HRD1-STING Axis to Mitigate Cholesterol-Induced VSMC Senescence.

Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang

Department of Critical Care Medicine, Zhongshan People's Hospital, Zhongshan, People's Republic of China.Department of Critical Care Medicine, Zhongshan People's Hospital, Zhongshan, People's Republic of China. · pubmed

Paper

Abstract

Vascular smooth muscle cells (VSMCs) are crucial components of the arterial wall, playing a vital role in maintaining vascular integrity and function. Previous studies have identified HRD1 as a potential target for alleviating senescence in VSMCs. Ginsenoside Rb1 has been shown to counteract endothelial cell senescence triggered by H

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Research summary

Ginsenoside Rb1 mitigates cholesterol-induced senescence in vascular smooth muscle cells by targeting the HRD1-STING axis. This research addresses cellular senescence, a key factor in aging and age-related vascular diseases, making it relevant to longevity studies.

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