Testosterone therapy effects adipose distribution in older females post hip-fracture: The STEP-HI study.

Jacob E Earp, Shangshu Zhao, Furong Xu, Chia-Ling Kuo, Jenna M Bartley, Richard H Fortinsky, Jatupol Kositsawat, Carlos O Rehbein, Ellen F Binder, Jennifer Stevens-Lapsley, George A Kuchel

Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA.Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA. · pubmed

Paper

Abstract

With aging and injury, females experience ectopic redistribution of appendicular adipose tissue (AAT) into the visceral compartment, where adipose tissue (VAT) becomes highly inflammatory and increases risk of reinjury and chronic illness. Therefore, strategies that can disrupt this unhealthy adipose redistribution after hip fracture injury are of great interest. We examined the effects of testosterone therapy on total adipose tissue (TAT) and adipose distribution in older females recovering from hip fracture.

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Research summary

Testosterone therapy may positively affect adipose distribution in older females recovering from hip fractures. This research addresses the underlying issue of unhealthy adipose redistribution, which is a significant concern in aging and age-related health decline.

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