Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging.

Dongxue Xue, Xin Su, Aaron Pambu Lelo, Yongjun Zhang, Xueqing Ba, Cheng-Gang Zou, Aohe Ma, Yao Liu, Xiaoxue Li

Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun, Jilin 130024, China.Key Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life Science, Northeast Normal University, Changchun, Jilin 130024, China. · pubmed

Paper

Abstract

Histone lysine methylation regulates the expressions of mitochondrial function-related genes, which presents a "nucleus-to-mitochondria" signal communication, playing a key role in aging control. However, the underlying mechanisms remain elusive due to the complexity of histone lysine methylation in transcription modulation. In this study, using

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Research summary

The paper claims that histone methyltransferase SET-18/SMYD2 activation of NADase TIR-1d/SARM1 increases mitochondrial reactive oxygen species (mtROS) to promote aging. This research addresses mechanisms related to aging control, focusing on the role of histone methylation in mitochondrial function, which is pertinent to understanding the biological processes of aging.

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