Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice.

Mia Y Kawaida, Abigail L Tice, Samuel Alvarez, Jacob A Lackey, Benjamin Izaguirre, Qingping Yang, Lan Wei-LaPierre, Russell T Hepple, Terence E Ryan

Department of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA.Department of Applied Physiology and Kinesiology, The University of Florida, Gainesville, Florida, USA. · pubmed

Paper

Abstract

L-Kynurenine (L-Kyn), a product of tryptophan catabolism, increases with age and has been associated with reduced physical function and increased frailty in humans. Robustly expressed in skeletal muscle, kynurenine aminotransferases (KATs) degrade L-Kyn into kynurenic acid and are regulated by the transcriptional co-regulator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α).

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Research summary

Elevating circulating L-Kynurenine promotes frailty in aging mice. This paper investigates a potential mechanism related to aging and frailty, focusing on L-Kyn as a factor that may influence physical function and aging processes.

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