Multi-omics-guided discovery: yeast protein alleviates glucocorticoid-induced muscle atrophy through dual activation of IGF-1/PI3K/Akt/FOXO and CaMKK/AMPK signaling pathways.

Yu Liang, Qiaocui Liu, Xing Zhang, Bin Li, Tao Hou

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. [email protected] of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. [email protected]. · pubmed

Paper

Abstract

Sarcopenia, an aging-related disorder characterized by progressive loss of skeletal muscle mass and function, lacks well-defined mechanisms and specific therapeutics. This study investigated the therapeutic effects of yeast protein (YP) on dexamethasone (DEX)-induced muscle atrophy in C57BL/6J mice using transcriptomic and metabolomic approaches. High-dose (2 g per kg bodyweight) YP (H-YP) significantly ameliorated muscle histopathology, increased serum CAT and SOD activity, enhanced grip strength and hanging endurance, elevated muscle ATP and IGF-1 levels, and reduced MSTN expression (

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Research summary

The paper claims that yeast protein alleviates glucocorticoid-induced muscle atrophy through the activation of specific signaling pathways. This research is relevant as it addresses muscle atrophy, a significant aspect of sarcopenia, which is directly related to aging and seeks to explore potential therapeutic interventions that could mitigate age-related muscle loss.

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