Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism.

Jiaying Yu, Yiran Wang, Nan Wang, Yizhi Zhang, Qi Yu, Jingjing Li, Runan Zhang, Fanyun Wang, Qianru Zhang, Jiaqi Zhang, Jiayu Zhu, Weili Xu, Bo Peng, Bo Qu, Liyan Liu, Rennan Feng

Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, PR China; Key Laboratory of Precision Nutrition and Health of Ministry of Education, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, PR China; School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, PR China.Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, PR China; Key Laboratory of Precision Nutrition and Health of Ministry of Education, School of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, PR China; School of Nursing, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, PR China. · pubmed

Paper

Abstract

Aging is characterized by the progressive decline of physiological integrity, and its driving factors include mitochondrial dysfunction, epigenetic changes and metabolic imbalance. Although some studies have shown that glycine (Gly) has anti-aging protection, its mechanism has not been clarified.

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Research summary

Glycine ameliorates aging-related dysfunctions by influencing mitochondrial one-carbon metabolism. The paper addresses mechanisms that may underlie aging processes, focusing on mitochondrial dysfunction, which is a key factor in the biology of aging.

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