Adipose-derived stem cell exosomes attenuated fibroblast senescence by regulating endoplasmic reticulum stress through SIRT1.

Yagang Ding, Bangde Xue, Mingkui Gao, Sibin Guan, Qinchuan Li, Jun Liu

Department of Cardiac Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Adipose-derived stem cells are widely used in aging field because of their extensive sources, low immunogenicity and strong secretory function. In particular, the exosomes of adipose-derived stem cells are rich in small molecules of RNA and protein. Studies have shown that exosomes also play a role in regulation of ER stress. Therefore, we hypothesized that exosomes of adipose-derived stem cells could regulate ER stress and delay fibroblasts senescence. In this study, we use H

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Research summary

The paper claims that exosomes derived from adipose-derived stem cells can regulate endoplasmic reticulum stress to delay fibroblast senescence. This research is relevant as it addresses mechanisms that could potentially mitigate cellular aging processes, contributing to the understanding of longevity and age-related cellular dysfunction.

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