LncRNA:CR43306 modulates testicular aging via cell adhesion in Drosophila.

Xiaorong Wang, Qiuru Huang, Zhenbei Li, Chenyu Wang, Xuxin He, Jiaxin Li, Xinda Wang, Ziwen Lin, Binbin Yang, Qingqing Hu, Qiushi Xia, Xiaoli Sun, Jun Yu, Yujuan Qi

Clinical Research Center for Reproductive Genetics of Nantong University, Center for Reproductive Medicine, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.Clinical Research Center for Reproductive Genetics of Nantong University, Center for Reproductive Medicine, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China. · pubmed

Paper

Abstract

The decline in testicular function with age has raised significant concerns. Long non-coding RNA (lncRNA) influences a wide array of physiological processes, including spermatogenesis. Nevertheless, the precise roles and regulatory mechanisms of lncRNA in testicular aging remain elusive. This investigation delves into the function of lncRNA:CR43306 in governing spermatogenesis during testicular aging. Depletion of lncRNA:CR43306 in 40-day-old Drosophila testes resulted in the hindrance of spermatogenesis, particularly affecting elongated spermatids, leading to functional senescence. Additionally, differentially expressed gene (DEG) expression analysis through bulk RNA-seq unveiled genes linked to elongated spermatids and cell adhesion. Our findings underscore the pivotal role of lncRNA:CR43306 in testicular aging by influencing cell adhesion. These discoveries illuminate the regulatory pathways of lncRNA in testicular aging and offer valuable insights for potential studies and therapeutic interventions.

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Research summary

LncRNA:CR43306 plays a crucial role in modulating spermatogenesis during testicular aging in Drosophila. The study addresses the mechanisms of aging at a cellular level, specifically in the context of reproductive aging, which is a significant aspect of overall longevity research.

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