High-protein diet promotes aging by activating the CG6415/AMT gene and disrupting mitochondrial homeostasis.

Xiaoqing Xu, Wangyang Zheng, Qianmin Liu, Yue Li, Shuo Yang, Runyi Zhou, Yina Wang, Xiang Qi, Can Zhang, Fengmin Zhang, Yue Wu, Yuhao Li, Ying Li

Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin 150081, China.Department of Nutrition and Food Hygiene, the National Key Discipline, School of Public Health, Harbin Medical University, Harbin 150081, China. · pubmed

Paper

Abstract

Dietary protein has multiple physiological functions. However, high-protein diets have been proven to elevate the risk of all-cause mortality. Aging is a dynamic and complex process, but the impact of dietary protein on aging remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that high-protein diets accelerate aging by activating the CG6415/AMT gene, which disrupts mitochondrial homeostasis. This is relevant because it investigates a specific molecular mechanism linking dietary intake to the fundamental biological processes of aging and mitochondrial dysfunction, rather than merely treating age-related symptoms.

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