Shorter kidney telomeres are associated with nephrosclerosis by an epigenetic signature.

Olutope Arinola Akinnibosun, Xiaoguang Xu, Amber Emmett, Huy Nguyen, Shadi Hames-Fathi, Maciej Drzal, James Eales, David Scannali, Priscilla R Prestes, Matthew Denniff, Pawel Bogdanski, Joanna Zywiec, Wojciech Wystrychowski, Ewa Zukowska-Szczechowska, Tomasz J Guzik, Nilesh J Samani, John Dormer, Maciej Tomaszewski, Fadi J Charchar

Health Innovation and Transformation Centre, Federation University Australia, Ballarat, VIC 3353, Australia.Health Innovation and Transformation Centre, Federation University Australia, Ballarat, VIC 3353, Australia. · pubmed

Paper

Abstract

Ageing leads to a progressive loss in structural integrity and a functional decline of human organs, alongside telomere attrition and alterations in DNA methylation patterns. Their relationships in the human kidney in the context of ageing remain elusive.

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Research summary

Shorter kidney telomeres are associated with nephrosclerosis by an epigenetic signature. The paper explores the relationship between telomere attrition and kidney health, which is pertinent to understanding aging mechanisms and their impact on organ function.

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