Linking intestinal bitter taste receptors and GSPE-induced long-lasting benefits in ageing rats: an integrative analysis.

Adrià Vilalta, Maria Descamps-Solà, Marta Sierra-Cruz, Alba Miguéns-Gómez, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Montserrat Pinent, Maria Teresa Blay, Anna Ardévol, Ximena Terra

Universitat Rovira i Virgili, Departament Bioquímica i Biotecnologia, MoBioFood Research Group, C/Marcel·lí Domingo 1, 43007 Tarragona, Spain.Universitat Rovira i Virgili, Departament Bioquímica i Biotecnologia, MoBioFood Research Group, C/Marcel·lí Domingo 1, 43007 Tarragona, Spain. · pubmed

Paper

Abstract

Ageing is associated with attenuated type-2 bitter-taste receptor (TAS2R) signalling and contributes to metabolic, inflammatory and barrier decline, but its system-wide impact along the gut remains undefined. We combined transcription analysis, physiology, metabolomics and microbiota profiling to test whether a brief grape-seed proanthocyanidin extract (GSPE) intervention can counter age-related dysfunction by long-term modulation of intestinal

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that a brief intervention with grape-seed proanthocyanidin extract can lead to long-term benefits in age-related gut dysfunction. This research addresses the underlying mechanisms of aging by exploring the modulation of intestinal receptors and their systemic effects, which is pertinent to longevity studies.

Author of this paper? Send a correction.