Disruption of ATP Synthase Spatiotemporal Organization, Ca

Silke Morris, Nico Marx, Gonzalo Barrientos, Isidora Molina-Riquelme, Frank Schmelter, Hugo E Verdejo, Stefan Peischard, Guiscard Seebohm, Verónica Eisner, Karin B Busch

Institute of Integrative Cell Biology and Physiology, Faculty of Biology, University of Muenster, Muenster, Germany.Institute of Integrative Cell Biology and Physiology, Faculty of Biology, University of Muenster, Muenster, Germany. · pubmed

Paper

Abstract

Heart disease is the leading cause of death in the elderly population. Age-related heart failure is frequently associated with energy deficits in cardiomyocytes. These cells rely on their abundant, cristae-rich mitochondria for ATP production. ATP synthase, localized along the cristae rims, is central to this process. It is presumed that its function is tightly bound to its spatial organization, but details remain unclear. Here, we explored the spatiotemporal organization of ATP synthase in senescent human iPSC-derived CM in conjunction with its functions. We found changes in the stoichiometry of F

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Research summary

The paper claims that changes in the spatiotemporal organization of ATP synthase in senescent cardiomyocytes affect its function. This research is relevant as it investigates the underlying mechanisms of energy deficits in aging heart cells, which could contribute to understanding age-related heart failure.

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