Lifelong cGAS deficiency leads to altered lipid storage and cholesterol homeostasis.

Daniela Carrillanca, Ian Riquelme, Matías Mansilla-Jaramillo, Camila Sánchez-Pérez, Andrea Monterroza, Natalia Lepio, Fabián Rojas, Gonzalo I Cancino, Paola Murgas

Facultad de Medicina, Instituto de Inmunología y Parasitología, Universidad Austral de Chile, Valdivia, Chile.Facultad de Medicina, Instituto de Inmunología y Parasitología, Universidad Austral de Chile, Valdivia, Chile. · pubmed

Paper

Abstract

The complex interaction between the immune system and metabolic homeostasis is becoming recognized, as immune sensors affect key metabolic tissues, including the liver and adipose tissue. The cGAS-cGAMP-STING pathway, previously recognized as a cytosolic DNA-sensing pathway, is currently associated with lipid metabolism in addition to its inflammatory function. Although STING is acknowledged for its connection to cholesterol, the metabolic functions of its upstream component molecules-the DNA sensor cGAS and the resulting product cGAMP-are largely unexplored. We propose that cGAS and cGAMP serve as crucial, previously unidentified regulators of systemic lipid homeostasis throughout the lifetime.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

cGAS and cGAMP are proposed as crucial regulators of systemic lipid homeostasis throughout the lifetime. The paper explores the role of immune sensors in metabolic processes, which could have implications for understanding aging and metabolic diseases related to longevity.

Author of this paper? Send a correction.