Peripheral blood mononuclear cell mitochondrial bioenergetics are related to vascular endothelial function in young and older adults.

S Tony Wolf, James F Bangle, William E Jennings, Georgia R Albino, Melissa Gorejena, Briana L Clary, Junwon Heo, Jarrod A Call

Department of Kinesiology, University of Georgia, Athens, GA, 30602.Department of Kinesiology, University of Georgia, Athens, GA, 30602. · pubmed

Paper

Abstract

The use of peripheral blood mononuclear cells (PBMCs) in cardiovascular research is increasingly common. However, little is known regarding potential age-related changes in mitochondrial bioenergetics and oxidative stress in PBMCs, or whether such changes relate to endothelial function. We assessed mitochondrial bioenergetics and antioxidant buffering capacity (AoxBC) capacity in PBMCs from young (n=18; 21±2 yrs) and older (n=17, 66±4 yrs) adults. High-resolution respirometry and fluorometry measured mitochondrial respiration rate (

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Research summary

The study investigates the relationship between mitochondrial bioenergetics in PBMCs and vascular endothelial function across different age groups. This research is relevant as it explores potential age-related changes in cellular mechanisms that could contribute to understanding the biological processes of aging and longevity.

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