Poliumoside attenuates endothelial senescence and atherosclerosis by regulating MKRN2-mediated autophagy via the PI3K/AKT/ mTOR pathway.
Abstract
Endothelial senescence contributes to the development and progression of atherosclerosis. Poliumoside (Pol), a natural compound with diverse bioactivities, has been shown to attenuate oxidative stress and inflammation, major triggers of senescence. As the role of Pol in Human Umbilical Vein Endothelial Cells (HUVECs) senescence remains elusive, this study aimed to determine whether Pol protects against atherosclerosis by modulating senescence in HUVECs and to elucidate the underlying mechanisms. In the present study, compared with ApoE
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Research summary
Poliumoside protects against atherosclerosis by modulating endothelial senescence through MKRN2-mediated autophagy via the PI3K/AKT/mTOR pathway. This study addresses the mechanisms of endothelial senescence, which is a contributing factor to aging and age-related diseases, thus making it relevant to longevity research.
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