Sleep, Metabolites, and Global Cognition: A Mediation Analysis of Plasma Metabolic Profiles in the West China Health and Aging Cohort.

Xueyao Wu, Qingwen Zhao, Xingyu Zhang, Haiyu Yan, Xinyang Dui, Ke Jiang, Xin Chen, Lei Lin, Tianpei Ma, Xunying Zhao, Jinyu Xiao, Tao Zhang, Lu Long, Jiaqiang Liao, Xia Jiang, Jiayuan Li

West China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.West China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. · pubmed

Paper

Abstract

Growing evidence connects sleep disorders with cognitive impairment in older adults, though underlying biological mechanisms remain unclear. We investigated how plasma metabolic profiles mediate the relationship between sleep patterns and global cognition.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that plasma metabolic profiles mediate the relationship between sleep patterns and global cognition in older adults. This research is relevant as it explores biological mechanisms linking sleep and cognition, which could contribute to understanding aging processes and cognitive decline.

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