Accelerated epigenetic aging and shorter DNA methylation-based telomere length in sarcopenic obesity: an exploratory pilot study.

Ana Claudia Rossini Venturini, Caroline Fogagnolo, Gabriela Ueta Ortiz, Guilherme da Silva Rodrigues, Arthur Polveiro da Silva, Natália Yumi Noronha, Gabriela Ferreira Abud, Bianca Monteiro Silva, Gabriela Geraldo Benzoni, Marcela Augusta de Souza Pinhel, Lígia Moriguchi Watanabe, Chanachai Sae-Lee, Sofia Germano Travieso, Marcela Coffacci de Lima Viliod, Carla Barbosa Nonino, Adelino Sanchez Ramos da Silva, Ellen Cristini de Freitas

School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil. · pubmed

Paper

Abstract

Sarcopenic obesity (SO), defined as the coexistence of excess fat mass and low muscle mass/function, has been linked to adverse outcomes. Epigenetic alterations are central hallmarks of aging. Evaluating how obesity, sarcopenia, and SO are related to epigenetic aging biomarkers may provide insights into cellular aging and disease risk.

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Research summary

The paper claims that accelerated epigenetic aging and shorter DNA methylation-based telomere length are associated with sarcopenic obesity. This study explores the relationship between epigenetic aging biomarkers and a condition that may reflect underlying mechanisms of aging, thus contributing to the understanding of age-related diseases.

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