exBAClock: A comprehensive database of published clocks for age quantification and age-related diseases.

Anastasiya Kobelyatskaya, Anastasiya Novoselova, Ksenia Bylinskaya, Nikolai Nemirovich-Danchenko, Mikhail Ivanchenko, Claudio Franceschi, Alexey Moskalev

Institute of Biology of Aging and Healthy Longevity Medicine with Preventive Medicine Clinic, Petrovsky Russian Research Centre of Surgery, Moscow, Russia. Electronic address: [email protected]. · pubmed

Paper

Abstract

Biological age, as opposed to chronological age, quantifies the body's functional state and rate of aging. Despite the absence of a universal formula for its determination, panels of biomarkers that change consistently with age are used to construct predictive aging clocks. These models enable the identification of accelerated aging and are valuable as surrogate endpoints in clinical trials. The proliferation of published aging clocks has created a challenge: data is fragmented across numerous publications, making manual extraction and analysis highly labor-intensive. To consolidate this information, we present exBAClock, a comprehensive, web-based database for exploring aging clocks (https://akob.shinyapps.io/exbaclock/). exBAClock integrates multiple functional modules, featuring structured tables on clocks (over 100 formulas from 95 publications), their predictors, and their associations with diseases, mortality, lifestyle, and clinical trials (about 270 more articles).

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Research summary

The paper presents exBAClock, a database that consolidates various aging clocks and their associations with age-related diseases. This work is relevant as it addresses the quantification of biological age, which is crucial for understanding the aging process and developing interventions that could potentially extend lifespan or improve health in aging populations.

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