MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis.

Le Shi, Zehui Sun, Yingxue Cao, Yuying Li, Wenjie Qing, Lingli Zhou, Mingming Xu, Xiaomei Mai, Lechun Ou, Xiaoping Yang, Delaram Shakiba, Kaoru Ri, Wangsheng Ou, Jun Chen, Avi Rosenberg, Jean-François Trempe, Edward A Fon, Xialin Liu, Yihai Cao, Elia J Duh, Wei Yi

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou 510060, China. · pubmed

Paper

Abstract

Mitochondrial dysfunction is a hallmark of aging and a key contributor to age-related diseases including cardiovascular disease. However, molecular pathways that safeguard mitochondrial homeostasis in the aging heart remain poorly understood. Here, we identify MTFR1L as a regulator of mitophagy that binds p-S65-Ub, a key signal amplifying the PINK1/Parkin axis. We find that MTFR1L is enriched in metabolically active tissues, particularly in the heart, where it regulates Parkin signaling. Genetic deletion of

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

MTFR1L regulates mitophagy and mitochondrial homeostasis in the aging heart. The paper addresses a molecular pathway that contributes to mitochondrial dysfunction, a key factor in aging and age-related diseases, making it relevant to longevity research.

Author of this paper? Send a correction.