Cortical O

Hongyi Kang, Sitong Zhou, Michael Giannetto, Evan D McConnell, Ning Kang, Qian Sun, Hetince Zhao, Helen S Wei, Kevin Kramer, Yaojun Guo, Juliana S Costa, Saul A Villeda, Maiken Nedergaard, Jiandi Wan

Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642.Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642. · pubmed

Paper

Abstract

Current evidence suggests that the rejuvenating effects of parabiosis on brain function arise from the exchange of blood factors that enhance synaptic plasticity, promote neurogenesis, and reduce neuroinflammation in aged animals. However, aging is also associated with diminished tissue oxygenation. Here, we report that erythrocytes (red blood cells, RBCs) from aged mice exhibit reduced responsiveness to low oxygen tension (PO

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Research summary

The paper claims that aged erythrocytes have reduced responsiveness to low oxygen tension, which may impact brain function and aging. This research addresses a potential root cause of aging by exploring the effects of oxygenation on brain health, linking it to the broader context of age-related decline.

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